From “Idea Grants” for scientists to statewide networks studying specific cancers, Pelotonia donations have been used since 2009 to fund research projects that otherwise might have sat on shelves gathering dust.As some 8,000 riders prepare for the ninth annual cycling fundraiser being held in central Ohio this weekend, Ohio State University’s Comprehensive Cancer Center this week announced its latest round of Idea Grants, which will fund research into bladder, brain, breast, ovarian and thyroid cancers, as well as a form of leukemia.The eight grants are among more than 100 Idea Grants, totaling $11.6 million, awarded since Pelotonia started eight years ago. Each provides funding for two years.The awards go to projects that might not yet be advanced enough to receive grants from other sources, such as the federal government, said Miguel Perez, Pelotonia’s vice president of mission and brand.“What’s so exciting is that we are getting the ability to fund high-risk, high-reward research right here,” Perez said. “We are so willing to take these ideas. They have tons of merit, and they may be the next big breakthrough, the next thing bringing us forward.”
Research receiving Idea Grant moneyPelotonia funding of $1.1 million has been used for eight 2017 “Idea Grants” to further cancer research at the Comprehensive Cancer Center at Ohio State University’s Wexner Medical Center.Researchers who received funding will:• Investigate the mechanism by which a protein that stops the growth of ovarian cancer halts cancer stem-cell survival.• Look at how cellular metabolism is “reprogrammed” in glioblastoma, the most common type of malignant brain tumor, to help identify molecular targets for the disease.• Seek to develop pathological imaging tools to accurately stage and classify bladder cancer patients, allowing urologists to make appropriate treatment decisions.• Conduct a human pilot study seeking to confirm that a two-drug combination can eliminate metastatic solid tumors. One drug stops cells that interfere with the immune system’s ability to kill cancer; the other activates immune-boosting T-cells.• Continue two clinical trials exploring whether an anti-leukemia drug and a new targeted antibody are effective in treating acute myeloid leukemia, which affects blood-forming cells in bone marrow.• Study patient tumors and blood to learn how cancer cells become resistant in a subset of advanced papillarythyroid cancer.• Test the effectiveness of using radiation with immune modulating treatments to identify potential therapies forglioblastoma.• Seek to discover genetic differences in the general population that make people more susceptible to acute myeloid leukemia.Source: Comprehensive Cancer Center at Ohio State University Wexner Medical Center.From its inception until last year, Pelotonia raised more than $130 million for research efforts at the cancer center, which includes the James Cancer Hospital and the Solove Research Center as well as other hospitals. The funds have all been spent or allocated, Perez said, and this year’s goal is to raise a record $25.5 million.Along with Idea Grants, some Pelotonia funding has gone to statewide cancer research initiatives aimed at taking advanced clinical care and research to remote areas of the state.Among them is the Ohio Colorectal Cancer Prevention Initiative, which linked more than 50 hospitals to research the disease. Similar statewide initiatives have been established to study lung and endometrial cancers, projects that will be fully operational this year.
Source: Pelotonia donations being used on ‘high-risk, high-reward’ research